Monoclonal antibodies in the treatment of migraine

The most modern and most effective method of migraine treatment today is medication therapy based on antibodies. This method is also called anti-CGRP therapy, because the antibodies that are injected into the human body bind and deactivate the CGRP (calcitonin gene-related peptide) protein.

Research data have shown that during a migraine attack, the nerve endings of the trigeminal nerve release CGRP, which is accompanied by the development of an inflammatory reaction and vasodilation in the meninges. The patient experiences this reaction as a headache, nausea and increased sensitivity to light, sounds or smells. In chronic migraine, when the headache bothers more than half of the days per month, the concentration of CGRP in the nervous system is consistently elevated. If we bind CGRP or its receptor with monoclonal antibodies, we can significantly reduce the number of headache days, the number of migraine attacks, and significantly reduce their severity.

Monoclonal antibody injections for the treatment of migraine appeared in 2018, and one of these drugs (fremanezumab) has been available in Ukraine since July 2020. Our specialists were the first in our country to start prescribing it and since then are the most experienced in using anti-CGRP therapy.

Treatment consists of subcutaneous injections of an antibody medication (fremanezumab) once a month or once every three months, depending on the dose. The procedure is simple and safe and has no serious side effects.

Our specialists can advise you on the need to prescribe anti-CGRP monoclonal antibodies, perform the first injection, and help evaluate its results.

Fremanezumab is recommended for the preventive treatment of migraine in adults who have at least 4 attacks per month.

• Proven high efficiency

• Brevity of the procedure, lack of specific preparing

• Ability to combine with other methods as part of complex therapy

• Predicted effect, high safety profile

• Already after the first procedure, the patient feels relief, which becomes stable after a course of injections

1. A REALLY comprehensive examination before prescribing the procedure

2. TRULY qualified specialists with extensive experience in the use of monoclonal antibodies

3. REALLY high-quality, certified preparations of monoclonal antibodies for the treatment of migraine