Monoclonal antibodies in the treatment of migraine

The most modern and most effective method of migraine treatment today is medication therapy based on antibodies. This method is also called anti-CGRP therapy, because the antibodies that are injected into the human body bind and deactivate the CGRP (calcitonin gene-related peptide) protein.
Research data have shown that during a migraine attack, the nerve endings of the trigeminal nerve release CGRP, which is accompanied by the development of an inflammatory reaction and vasodilation in the meninges. The patient experiences this reaction as a headache, nausea and increased sensitivity to light, sounds or smells. In chronic migraine, when the headache bothers more than half of the days per month, the concentration of CGRP in the nervous system is consistently elevated. If we bind CGRP or its receptor with monoclonal antibodies, we can significantly reduce the number of headache days, the number of migraine attacks, and significantly reduce their severity.
Monoclonal antibody injections for the treatment of migraine appeared in 2018, and one of these drugs (fremanezumab) has been available in Ukraine since July 2020. Our specialists were the first in our country to start prescribing it and since then are the most experienced in using anti-CGRP therapy.
Treatment consists of subcutaneous injections of an antibody medication (fremanezumab) once a month or once every three months, depending on the dose. The procedure is simple and safe and has no serious side effects.
Our specialists can advise you on the need to prescribe anti-CGRP monoclonal antibodies, perform the first injection, and help evaluate its results.
Fremanezumab is recommended for the preventive treatment of migraine in adults who have at least 4 attacks per month.

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Proven high efficiency
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Brevity of the procedure, lack of specific preparing
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Ability to combine with other methods as part of complex therapy
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Predicted effect, high safety profile
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Already after the first procedure, the patient feels relief, which becomes stable after a course of injections
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A REALLY comprehensive examination before prescribing the procedure
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TRULY qualified specialists with extensive experience in the use of monoclonal antibodies
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REALLY high-quality, certified preparations of monoclonal antibodies for the treatment of migraine
16 reviews
We went to the doctor purposefully; we knew about the doctor, our neurosurgeon from Kherson recommended this doctor, and this doctor was also recommended in Kyiv. The doctor met all our requirements, needs, and questions. If necessary, we will definitely reach out again.
Nice clinic, polite staff at the reception, I was seen on time, the appointment with the neurologist lasted an hour, there was time to discuss all questions, the doctor prescribed treatment, the treatment is ongoing, I am waiting for the results of the treatment, I had no complaints about the doctor.
The doctor listened carefully to my complaints, recommended which procedures to undergo and which medications to take, I enjoyed communicating with her, she explained everything in an accessible way about what needed to be done.
I liked the doctor as a person and as a specialist. She explained everything clearly and directly, prescribed tests. I am very satisfied with the visit and liked the quality of service.
I recommend, a very good doctor! It is clear that the doctor is educated, understands everything, was able to partially solve our problem, does not impose anything unnecessary, devoted enough time to us, we were satisfied with the doctor.
I really liked the doctor, good attitude, attentive. He clearly assigns everything according to the diagnosis, nothing unnecessary. We are very satisfied with the appointment.
I am satisfied with the consultation with Dr. Beloshitsky Vadim Vasilievich. A attentive doctor who gives proper attention to patients.
The doctor was very likable as a person and as a specialist, very caring and attentive. I left satisfied.
He listened to me, clarified all the issues, diagnosed, said we will fight the problem, and we will find out what other issues may exist in the process.
I was satisfied with the appointment, the doctor is competent and explained everything in detail. I recommend!
102 reviews
An excellent clinic that specializes in the treatment of chronic pain. A professional approach, modern equipment, and attentive staff create a comfortable environment for patients. The treatment results exceed expectations – the pain has significantly decreased, and the quality of life has improved. I recommend it to anyone looking for effective help in dealing with pain.
Hello, my mother has had headaches (migraine) for over 20 years, and it got to the point where she was taking painkillers several times a day, leading to dependence and the feeling that nothing would help. However, after consulting many doctors and spending a lot of time and money, her condition only worsened because they were treating something entirely different, which only caused side effects. We decided to try the drug Azhovi, or rather botulinum toxin. We chose the SPRAVNO Pain Medicine Center because of their democratic prices, direct supplies, and confirmation of the quality and originality of the drug. Most importantly, the professionalism of Vadym Vasylovych Biloshytskyi, who established the correct diagnosis and prescribed treatment with Azhovi. The treatment is still ongoing, but already from the start, 80% of the pain has disappeared, the quality of life has changed, blood pressure has normalized, and muscle tone has improved.
I sincerely thank the doctor and the SPRAVNO staff! I recommend it.
For about 10 years, I have been suffering from migraines and tension headaches. The pain has become daily and unbearable over time. During the day, I could take 4-5 painkillers; some helped, some no longer did. I consulted various neurologists, who prescribed triptans and simply advised me to get pregnant, saying “the migraine might go away.”
I had already given up on the idea that someone could help me and was just relying on painkillers. Over time, I realized that it was impossible to live my whole life taking painkillers, as they were causing headaches too, and I started looking for a solution again.
I found the Spravno clinic, made an appointment for a consultation with Marina Vadymivna Biloshytska, and since then my life has been divided into before and after! I am happy to write this))
I have been undergoing treatment for half a year and have wonderful results; I haven’t taken painkillers for over a month now—this is already a small victory..!))
Marina Vadymivna is a fantastic professional, an excellent doctor, caring and attentive! In my years, I have rarely met such sincere and caring doctors; Marina Vadymivna is just like that.) She found an approach to my body, supported me through all stages of treatment, never left me with questions in my head, and selected a medication purely based on individual indicators..!
I am very grateful to the clinic; the administrator is always friendly and has connected me with the doctor whenever needed.
Marina Vadymivna Biloshytska is a neurologist whom I recommend from the bottom of my heart!
I want to express my immense gratitude to this clinic, especially to doctor Biloshytska M. V. Patients are treated here as unique individual cases, not just another conveyor belt patient, whose illness (and everything related to it) is not delved into. Attention to detail, masterful work (I go for botulinum toxin injections), and always a caring attitude. Of course, there is little joy when you have something that brought you to a pain medicine clinic, but it is pleasant to return here.
Thank you, Ruslan Yevheniyovych, for your help! A wonderful doctor, very attentive and knows his stuff.
Good afternoon, underwent a procedure for treating the trigeminal nerve at the center, very pleased with the staff, the facilities and the attentive care. Special thanks to Vadim Vasilievich. I highly recommend this center for examinations and procedures, very grateful
I have already been to see Dr. Biloshytska M.V. several times, and the doctor helped me get out of the critical condition I was in. Thank you very much for the help and treatment!
I recommend the SPRAVNO clinic and especially Dr. Biloshytska M.V. as a great specialist, as she helped me a lot.
I want to express my immense gratitude to the professionals in their field: neurosurgeon Vadim Vasilievich Biloshytsky and neurologist Marina Vadimivna Biloshytska, as well as the “SPRAVNO” clinic for their responsible and conscientious attitude towards their work and patients, for their high qualifications, and for their help in solving the problem. We succeeded!
I highly recommend them!!
Sincere recommendations
Doctor Inna Buvallo identified the cause of the pain and resolved it in one procedure
For about 8-9 years, I was looking for the cause of my headaches and was treated by various doctors. At the pain management center, SPRAVNO, Marina Vadimivna Biloshytska diagnosed me, prescribed treatment, and within two weeks, there was a positive result, for which I am very grateful to Marina Vadimivna.
I recommend it to everyone, a very good clinic.
I had a consultation with neurologist Buvailo I.V., a highly competent and attentive doctor. I received answers to all my questions and we developed a treatment plan.










